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Nature. 1997 May 1;387(6628):43-8.

A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression.

Author information

1
Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla 92093-0648, USA.

Abstract

Transcriptional repression by nuclear receptors has been correlated to binding of the putative co-repressor, N-CoR. A complex has been identified that contains N-CoR, the Mad presumptive co-repressor mSin3, and the histone deacetylase mRPD3, and which is required for both nuclear receptor- and Mad-dependent repression, but not for repression by transcription factors of the ets-domain family. These data predict that the ligand-induced switch of heterodimeric nuclear receptors from repressor to activator functions involves the exchange of complexes containing histone deacetylases with those that have histone acetylase activity.

PMID:
9139820
DOI:
10.1038/387043a0
[Indexed for MEDLINE]

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