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Vaccine. 1997 Feb;15(3):301-6.

Estimates of the effectiveness of a whole-cell pertussis vaccine from an outbreak in an immunized population.

Author information

1
Field Epidemiology Training Program, Laboratory Centre for Disease Control (LCDC), Ottawa, Canada.

Abstract

Pertussis has re-emerged as a public health problem in Canada in recent years, emphasizing concerns about the effectiveness of the currently licensed whole-cell vaccine. Following a 1994 outbreak in Nova Scotia, we conducted a case-control study of 483 children aged < 10 years to assess vaccine effectiveness. Ninety-three percent of children aged 6 months and above had received three or more doses of vaccine, however, only 78% had received age-appropriate immunization. Among children aged 4 years and more, vaccine effectiveness against laboratory-confirmed pertussis was 57% (95% CI, 23-77%) for age-appropriate immunization (five doses) vs partial or no immunization. Vaccine effectiveness increased with increasing number of doses from 25% (95% CI, -58-65%) for three or more doses to 55% (95% CI, -15-83%) for five doses, compared with 0-2 doses.

PMID:
9139490
DOI:
10.1016/s0264-410x(96)00176-4
[Indexed for MEDLINE]

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