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Cephalalgia. 1997 Apr;17(2):127-30; discussion 102.

Prophylactic treatment of migraine with gamma-linolenic and alpha-linolenic acids.

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Department of Anesthesiology, Municipal Hospital of Zehlendorf, Free University of Berlin, Germany.


Polyunsaturated fatty acids (PUFA) were administered to 168 patients over a period of 6 months in an open-label uncontrolled study. In 129 patients available for study, 86% experienced reduction in severity, frequency and duration of migraine attacks, 22% became free of migraine and more than 90% had reduced nausea and vomiting. Self-medication changed to simple analgesics in the majority except in 14% of patients without improvement.

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