Abstract
Genetic analysis of Drosophila has shown that a morphogenetic gradient of the Transforming Growth Factor-beta family member dpp patterns the embryonic dorsal-ventral axis. Molecular and embryological evidence from Xenopus has strongly suggested a similar role for Bmp-4, the dpp homolog, in patterning the dorsal-ventral axis of chordates. A recent report has now identified mutations in two genes, dino and swirl, that disrupt dorsal-ventral patterning in the zebrafish Danio rerio. Characterization of these mutations parallels findings from Drosophila, thus establishing a genetic framework for the analysis of dorsal-ventral patterning in a vertebrate.
MeSH terms
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Animals
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Bone Morphogenetic Protein 4
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Bone Morphogenetic Proteins / genetics
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Bone Morphogenetic Proteins / physiology
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Drosophila Proteins*
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Drosophila melanogaster / embryology*
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Drosophila melanogaster / genetics
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Embryo, Nonmammalian / physiology
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Embryo, Nonmammalian / ultrastructure
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Embryonic Induction / physiology
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Evolution, Molecular
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Gene Expression Regulation, Developmental*
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Genes
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Genes, Insect
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Genes, Regulator
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Insect Proteins / genetics
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Insect Proteins / physiology
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Morphogenesis / physiology*
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Xenopus Proteins
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Xenopus laevis / embryology*
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Xenopus laevis / genetics
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Zebrafish / embryology*
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Zebrafish / genetics
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Zebrafish Proteins
Substances
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Bone Morphogenetic Protein 4
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Bone Morphogenetic Proteins
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Drosophila Proteins
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Insect Proteins
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Xenopus Proteins
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Zebrafish Proteins
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bmp4 protein, Xenopus
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bmp4 protein, zebrafish
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dpp protein, Drosophila