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AIDS Res Hum Retroviruses. 1997 May 1;13(7):529-31.

An interactive Web site providing major histocompatibility ligand predictions: application to HIV research.

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TB/HIV Research Laboratory, Brown University School of Medicine, Providence, Rhode Island 02912, USA.


EpiMatrix/HIV, a tool that is currently available on the World Wide Web, enables researchers to screen HIV proteins for potential MHC ligands. We have performed a comparison of EpiMatrix predictions to 158 published allotype-specific HLA-associated peptides (MHC ligands) derived from 133 proteins. The top 10 ranked EpiMatrix predictions for each of the 158 HLA allotype-protein pairs were selected for comparison with these published ligands. EpiMatrix correctly identified 134 of 158 published ligands (85%). The algorithm is now available for use by the HIV research community at the URL http:/(/)

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