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J Nat Prod. 1997 Apr;60(4):397-8.

Modulation of lipoxygenase activity by bacterial hopanoids.

Author information

1
Eastern Regional Research Center, U.S. Department of Agriculture, Wyndmoor, Pennsylvania 19038, USA. rmoreau@arserrc.gov

Abstract

Tetrahydroxybacteriohopane (1), a bacterial hopanoid, inhibited soybean 15-lipoxygenase with an IC50 of about 10 microM. After per-O-acetylation of 1 no inhibition of the 15-lipoxygenase was observed. Two other bacterial hopanoids, tetrahydroxybacteriohopane glucosamine (2) and tetrahydroxybacteriohopane ether (3), stimulated the activity of soybean 15-lipoxygenase. The activities of two other arachidonic acid-metabolizing enzymes, human 5-lipoxygenase and prostaglandin H synthase, were unaffected by 1.

PMID:
9134748
DOI:
10.1021/np960611y
[Indexed for MEDLINE]

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