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J Nat Prod. 1997 Apr;60(4):382-4.

Selective cytotoxicity of ginkgetin from Selaginella moellendorffii.

Author information

1
National Research Institute of Chinese Medicine, Taipei, Taiwan.

Abstract

Bioassay-directed fractionation of an ethanolic extract of Selaginella moellendorffii has led to the isolation of a known biflavone, ginkgetin (1). A dose-dependent inhibition was observed with 1 on the growth of OVCAR-3 (human ovarian adenocarcinoma) cells with 50% inhibition occurring at 1.8 micrograms/mL. Nonbioactive fractions yielded four additional known biflavones, amentoflavone 7,4',7",4"'-tetramethyl ether, kayaflavone, podocarpusflavone A, and amentoflavone.

PMID:
9134745
DOI:
10.1021/np960608e
[Indexed for MEDLINE]

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