Send to

Choose Destination
Schizophr Res. 1997 Apr 11;24(3):349-55.

Parvalbumin-immunoreactive neurons are reduced in the prefrontal cortex of schizophrenics.

Author information

Department of Biomedical Science, University of Sheffield, UK.


Recent studies have provided evidence for a functional impairment of gamma-aminobutyric acid (GABA)-containing interneurons in the prefrontal cortex of schizophrenics. This evidence includes reported deficits of basket and chandelier cells, which are known to contain the calcium-binding protein parvalbumin. Using a monoclonal antibody against parvalbumin we investigated possible changes in this subpopulation of neurons in the prefrontal cortex of schizophrenic cases and controls. Significantly reduced numbers of parvalbumin-immunoreactive neurons were observed in laminae III and IV, while no difference was detected in cortical width. Our findings are consistent with damage following a toxic insult, occurring during a developmental 'window of vulnerability' and specifically affecting this subpopulation of GABAergic neurons.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center