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Schizophr Res. 1997 Apr 11;24(3):349-55.

Parvalbumin-immunoreactive neurons are reduced in the prefrontal cortex of schizophrenics.

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1
Department of Biomedical Science, University of Sheffield, UK.

Abstract

Recent studies have provided evidence for a functional impairment of gamma-aminobutyric acid (GABA)-containing interneurons in the prefrontal cortex of schizophrenics. This evidence includes reported deficits of basket and chandelier cells, which are known to contain the calcium-binding protein parvalbumin. Using a monoclonal antibody against parvalbumin we investigated possible changes in this subpopulation of neurons in the prefrontal cortex of schizophrenic cases and controls. Significantly reduced numbers of parvalbumin-immunoreactive neurons were observed in laminae III and IV, while no difference was detected in cortical width. Our findings are consistent with damage following a toxic insult, occurring during a developmental 'window of vulnerability' and specifically affecting this subpopulation of GABAergic neurons.

PMID:
9134596
[Indexed for MEDLINE]
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