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Neurosci Lett. 1997 Mar 7;224(1):21-4.

A fixed morning awakening coupled with a low intensity light maintains a phase advance of the human circadian system.

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1
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

Abstract

The next day after an early morning awakening of human subjects coupled with a single exposure to bright light from 0600 to 0900 h, the salivary melatonin rhythm was phase advanced by about 1 h as compared with the pre-treatment profile. The phase advance was maintained for 4 days when the subjects adhered to the 0600 h awakening coupled with just low intensity light, but vanished when they slept till 0900 h. Similarly, 3 days following a twice repeated exposure to bright light from 0600 to 0900 h coupled with an early morning awakening, the salivary melatonin rhythm was phase advanced relative to the pre-treatment profile only in the subjects who adhered to the 0600 h awakening but not in those who slept till 0900 h. The findings may be used for treatment of chronobiological disorders.

PMID:
9132681
[Indexed for MEDLINE]
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