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Int Arch Allergy Immunol. 1997 May-Jul;113(1-3):206-8.

Molecular mechanisms of defective eosinophil apoptosis in diseases associated with eosinophilia.

Author information

1
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos. hus@SIAF.unizh.ch

Abstract

Apoptosis is a necessary process to maintain correct cell numbers in a multicellular organism. Defects in this process may contribute to the pathogenesis of a number of human diseases. We have suggested that inhibition of apoptosis in eosinophils by cytokines such as IL-5 and GM-CSF may play an important role in the pathogenesis of allergic disorders. Here, we review our recent progress in understanding the processes regulating eosinophil apoptosis.

PMID:
9130524
DOI:
10.1159/000237548
[Indexed for MEDLINE]

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