Format

Send to

Choose Destination
J Infect Dis. 1997 May;175(5):1115-20.

Identification of key gene products required for acquisition of plasmin-like enzymatic activity by group A streptococci.

Author information

1
Department of Microbiology, Medical College of Ohio, Toledo 43699-0008, USA.

Abstract

Group A streptococci incubated in human plasma can acquire a plasmin-like enzymatic activity. This process involves at least two bacterial proteins and two human protein cofactors. In this study, the key bacterial proteins were identified by using a series of isogenic mutants of group A isolate, CS101. These studies confirm a key role for the secreted plasminogen activator, streptokinase, and identify the major surface fibrinogen-binding protein as the product of the mrp gene. The requirement for human fibrinogen and plasminogen as key cofactors was also confirmed.

PMID:
9129074
DOI:
10.1086/516450
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center