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J Infect Dis. 1997 May;175(5):1115-20.

Identification of key gene products required for acquisition of plasmin-like enzymatic activity by group A streptococci.

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Department of Microbiology, Medical College of Ohio, Toledo 43699-0008, USA.


Group A streptococci incubated in human plasma can acquire a plasmin-like enzymatic activity. This process involves at least two bacterial proteins and two human protein cofactors. In this study, the key bacterial proteins were identified by using a series of isogenic mutants of group A isolate, CS101. These studies confirm a key role for the secreted plasminogen activator, streptokinase, and identify the major surface fibrinogen-binding protein as the product of the mrp gene. The requirement for human fibrinogen and plasminogen as key cofactors was also confirmed.

[Indexed for MEDLINE]

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