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Urol Clin North Am. 1997 May;24(2):269-73.

Progress in standardization of immunoassays for prostate-specific antigen.

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Department of Urology, Stanford University Medical Center, California, USA.


A calibrator composed of 90% prostate-specific antigen-alpha 1-antichymotrypsin (PSA-ACT) and 10% free PSA reduces the variation in control serums with widely divergent amounts of free PSA, from a mean of 28% among nine different assays to 9% after recalibration. The lyophilized form of the Stanford 90:10 calibrator is stable and therefore an excellent candidate for international standardization of PSA assays.

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