Format

Send to

Choose Destination
See comment in PubMed Commons below
Vet J. 1997 Jan;153(1):31-9.

Studies of canine leucocyte antigens: a significant advance in canine immunology.

Author information

  • 1Department of Veterinary Basic Sciences, Royal Veterinary College, London, UK.

Abstract

The Canine Leucocyte Antigen Workshop (CLAW) was set up to produce and circulate monoclonal antibodies directed against cell surface molecules defining specific leucocyte cell types in the dog. The antibodies produced by the workshop have been used in studies of the canine immune system. While many similarities between the dog and other animals have been demonstrated, workshop studies have identified some anomalies in this species: CD4 antigen for example is expressed not only on helper/inducer T-lymphocytes but also at high density on canine neutrophils. Workshop antibodies have been used to investigate lymphocyte populations in the normal dog and in a range of diseases from lymphocytic neoplasms through conditions with an immune-mediated component such as Leishmaniasis to potentially autoimmune disorders such as rheumatoid arthritis and chronic superficial keratitis.

PMID:
9125354
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center