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Arch Surg. 1997 Mar;132(3):264-7.

The prognostic significance of proliferating cell nuclear antigen in patients with lymph node-positive breast cancer.

Author information

1
Department of Surgery, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Republic of China.

Abstract

OBJECTIVE:

To evaluate the prognostic significance of proliferating cell nuclear antigen (PCNA) in patients with lymph node-positive primary breast cancer.

DESIGN:

A retrospective study.

SETTING:

A tertiary care hospital.

STUDY PARTICIPANTS:

A consecutive series of 123 patients with lymph node-positive primary breast cancer.

INTERVENTION:

The PCNA-labeling index [(PCNA-positive cells/1000 cells) x 100] was quantified in paraffin-embedded tissue specimens from 123 patients with lymph node-positive primary breast cancer by immunohistochemical staining. Other important clinicopathological variables, including estrogen receptor status, histological grade, lymph node status, primary tumor status, ploidy pattern, S-phase fraction, and TNM staging, were also identified and evaluated.

MAIN OUTCOME MEASURES:

The influence of the PCNA-labeling index on the disease-free survival rate and overall survival rate.

RESULTS:

The PCNA-labeling index of the tissue specimens tested from 123 patients ranged from 11% to 82%. The PCNA-labeling index was closely related to primary tumor status, histological grade, TNM staging, and S-phase fraction. Between patients with a high PCNA-labeling index (> 35%) and those with a low PCNA-labeling index (< or = 35%), there were significant (P < .01) differences in both 5-year disease-free survival rates (2% vs 85%) and 5-year overall survival rates (2% vs 92%). When the PCNA-labeling index and all the clinicopathologic variables were entered into a multivariate analysis for either disease-free survival or overall survival by the Cox proportional hazards model, the PCNA-labeling index emerged as an independent prognostic factor.

CONCLUSION:

Based on our results, the PCNA-labeling index potentially is a useful prognostic factor for lymph node-positive primary breast cancer.

[Indexed for MEDLINE]

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