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Nature. 1997 Mar 27;386(6623):360-6.

Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb.

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  • 1Gene Expression Laboratory, The Salk Institute, La Jolla, California 92037, USA.

Erratum in

  • Nature 1997 Aug 28;388(6645):906.


Vertebrate limb outgrowth requires a structure called the apical ectodermal ridge, formation of which follows the previous establishment of the dorsoventral limb axis. Radical fringe is expressed in the dorsal ectoderm before the ridge appears, and is repressed by Engrailed-1, which is expressed in the ventral ectoderm. Misexpression of these genes indicates that a ridge is formed wherever there is a boundary between cells expressing and not expressing Radical fringe. Thus, as in Drosophila, Radical fringe positions the ridge at the dorsoventral limb boundary.

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