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J Surg Oncol. 1997 Mar;64(3):202-6.

Prognostic factors in patients with recurrent differentiated thyroid carcinoma.

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1
The Second Department of Internal Medicine, Osaka University Medical School, Japan.

Abstract

BACKGROUND:

Approximately 20% of patients with thyroid carcinoma have relapse. To evaluate the factors affecting their disease-free survival and prognosis, we studied 68 patients with recurrent differentiated thyroid carcinoma, ranging in age from 5 to 73 years (mean: 47.6 years). Three-fourths of patients were followed for >10 years. Thirty-nine patients were treated with total or subtotal thyroidectomy at first operation; the remainder underwent lesser operations. Fifty-six patients had local recurrence, mostly lymph node infiltration. Twenty-six patients died.

METHODS:

Survival curves were constructed using the Kaplan-Meier method. Factors affecting relapse and survival were tested by univariate or multivariate analysis.

RESULTS:

Univariate analysis identified age at diagnosis, local tumor extension, and surgical method as significant factors for disease-free survival. These three factors and histology were significant prognostic factors. Multivariate analysis showed age, histology, and disease-free interval as significant and independent variables.

CONCLUSIONS:

In high-risk patients, complete resection of thyroid tissue and cervical lymph nodes is critical.

PMID:
9121150
[Indexed for MEDLINE]
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