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Eur J Obstet Gynecol Reprod Biol. 1996 Dec 27;70(2):191-6.

Mechanical stretching induces interleukin-8 gene expression in fetal membranes: a possible role for the initiation of human parturition.

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1
Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Japan.

Abstract

OBJECTIVE:

Interleukin-8 (IL-8) is known to play a crucial role in human parturition. We aimed to study the effect of mechanical stretching on the expression of IL-8 in fetal membranes (amniochorion) and decidua.

STUDY DESIGN:

We examined the expression of IL-8 and its receptor in fetal membranes (amniochorion) and decidua by immunohistochemical staining. Also, we studied the synthesis of IL-8 messenger RNA (mRNA) in the fetal membranes before and after stretching.

RESULTS:

We found that mechanical stretching within physiological limit increased IL-8 messenger RNA (mRNA) synthesis in fetal membranes and decidua in a time- and load-dependent manner. Application of mechanical force led to markedly increased staining of IL-8 receptor in decidual cells but not in amnion or chorion cells.

CONCLUSION:

These results suggested that mechanical stretching was a candidate for one of the signals important for production of IL-8 in fetal membranes and decidua and probably for initiation of a cytokine network at amniochorio-decidual interface through increased expression of IL-8 receptors.

PMID:
9119102
[Indexed for MEDLINE]
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