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Cell. 1997 Mar 21;88(6):833-43.

Notch activity influences the alphabeta versus gammadelta T cell lineage decision.

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  • 1Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.

Abstract

The choice between the alphabeta or gammadelta T cell fates is influenced by the production of functional, in-frame rearrangements of the TCR genes, but the mechanism that controls the lineage choice is not known. Here, we show that T cells that are heterozygous for a mutation of the Notch1 gene are more likely to develop as gammadelta T cells than as alphabeta T cells, implying that reduced Notch activity favors the gammadelta T cell fate over the alphabeta T cell fate. A constitutively activated form of Notch produces a reciprocal phenotype and induces thymocytes that have functional gammadeltaTCR gene rearrangements to adopt the alphabeta T cell fate. Our data indicate that Notch acts together with the newly formed T cell antigen receptor to direct the alphabeta versus gammadelta T cell lineage decision.

PMID:
9118226
[PubMed - indexed for MEDLINE]
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