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Cell. 1997 Mar 21;88(6):747-56.

Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer.

Author information

1
Department of Biological Chemistry, University of California, Los Angeles 90095-1662, USA.

Abstract

Frzb-1 is a secreted protein containing a domain similar to the putative Wnt-binding region of the frizzled family of transmembrane receptors. Frzb-1 is widely expressed in adult mammalian tissues. In the Xenopus gastrula, it is expressed and regulated as a typical Spemann organizer component. Injection of frzb-1 mRNA blocks expression of XMyoD mRNA and leads to embryos with enlarged heads and shortened trunks. Frzb-1 antagonizes the effects of Xwnt-8 ectopic expression in a non-cell-autonomous manner. Cultured cells transfected with a membrane-tethered form of Wnt-1 bind epitope-tagged Frzb-1 in the 10(-10) M range. The results strengthen the view that the Spemann organizer is a source of secreted inhibitory factors.

PMID:
9118218
PMCID:
PMC3061830
DOI:
10.1016/s0092-8674(00)81921-2
[Indexed for MEDLINE]
Free PMC Article

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