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Neurodegeneration. 1996 Dec;5(4):473-6.

Brain energy metabolism, cognitive function and down-regulated oxidative phosphorylation in Alzheimer disease.

Author information

1
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA. sir@helix.nih.gov

Abstract

Reduced brain glucose utilization in early stages of Alzheimer disease, as measured with in vivo positron emission tomography, reflects potentially reversible down-regulation of gene expression for oxidative phosphorylation within neuronal mitochondria. Such down-regulation may occur when neuronal energy demand is first reduced by synaptic dysfunction or loss.

PMID:
9117565
DOI:
10.1006/neur.1996.0065
[Indexed for MEDLINE]

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