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Curr Opin Genet Dev. 1997 Apr;7(2):220-32.

Life and death in the cytoplasm: messages from the 3' end.

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Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, 53706, USA.


The cytoplasmic life of an mRNA revolves around the regulation of its localization, translation and stability. Interactions between the two ends of the mRNA may integrate translation and mRNA turnover. Regulatory elements in the region between the termination codon and poly(A) tail - the 3' untranslated region - have been identified in a wide variety of systems, as have been some of the key players with which these elements interact.

[Indexed for MEDLINE]

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