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Curr Opin Genet Dev. 1997 Apr;7(2):152-7.

Chromatin proteins involved in the initiation of DNA replication.

Author information

1
Imperial Cancer Research Fund, Clare Hall Laboratories, Blanche Lane, South Mimms, Potters Bar, Hertfordshire, EN6 3LD, UK. rowles@icrf.icnet.uk

Abstract

Eukaryotic DNA replication is regulated at least in part by the assembly of initiation proteins onto origins of replication. The origin recognition complex (ORC) is bound to origins throughout most of the cell cycle. Other initiation proteins, such as Cdc6 and the MCM/P1 proteins, are assembled onto ORC-containing chromatin during G1 to define a prereplicative complex. During S phase, these proteins are displaced from chromatin and their reassembly is inhibited by protein-dependent kinases.

PMID:
9115430
DOI:
10.1016/s0959-437x(97)80123-2
[Indexed for MEDLINE]

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