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Curr Opin Genet Dev. 1997 Apr;7(2):233-41.

Translational controls impinging on the 5'-untranslated region and initiation factor proteins.

Author information

1
Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, UK. rjj@mole.bio.cam.ac.uk

Abstract

Translation of eukaryotic mRNAs is generally initiated by the scanning ribosome mechanism. This can be downregulated by high affinity protein binding to cap-proximal RNA motifs. Translation can also be regulated by short open reading frames within the 5' -untranslated region. A key factor for initiation is elF4F, in which one of the polypeptide chains, elF4G, seems to have a bridging function and binds three other factors at separate sites: elF4E (the cap-binding factor), the helicase elF4A, and elF3, which also interacts with 40S ribosomal subunits. Initiation is regulated by the MAP kinase and rapamycin-sensitive signalling pathways, which control phosphorylation of elF4E and 4E-BP1, a protein which in the dephosphorylated form binds and sequesters elF4E.

PMID:
9115426
DOI:
10.1016/s0959-437x(97)80133-5
[Indexed for MEDLINE]

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