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Chem Biol. 1997 Mar;4(3):187-94.

Protein splicing: occurrence, mechanisms and related phenomena.

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  • 1Gryphon Sciences, 250 East Grand Avenue, Suite 90, South San Francisco, CA 94080, USA.


An increasing number of proteins are thought to self-splice post-translationally on the level of the polypeptide, producing two separate proteins from one gene, neither of which is the protein predicted from the gene sequence. The recent elucidation of the mechanism of splicing has led to the identification of a number of post-translational protein modifications that use similar chemical pathways.

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