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South Med J. 1997 Apr;90(4):395-8.

Transverse leukonychia in patients receiving cancer chemotherapy.

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Department of Internal Medicine, University of Texas-Houston Medical School 77030, USA.


Transverse white nail banding can be inherited or caused by a variety of diseases and medications, including cancer chemotherapeutic agents. We report three cases in which patients with cancer had antineoplastic therapy-induced transverse leukonychia and summarize previously published reports. There is no specific cancer chemotherapeutic drug, combination of drugs, or drug class that causes transverse leukonychia; however, cyclophosphamide, doxorubicin, and vincristine are the therapeutic agents most frequently involved. For patients receiving cancer chemotherapy, white transverse nail banding is a side effect of the medication rather than a consequence of underlying malignancy.

[Indexed for MEDLINE]

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