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Cell Signal. 1997 Feb;9(2):141-51.

Does subunit dissociation necessarily accompany the activation of all heterotrimeric G proteins?

Author information

1
Membrane Biochemistry Section, NINDS, NIH, Bethesda, MD 20892, USA.

Abstract

Heterotrimeric (alpha beta gamma) G proteins mediate a variety of signal transduction events in virtually every cell of every eukaryotic organism. The predominant hypothesis is that dissociation of the alpha-subunit from the G beta gamma-subunit complex necessarily accompanies the activation of these proteins, and that the alpha-subunit is primarily responsible for regulating the response of effector molecules. However, there is increasing evidence that both the alpha-subunit and the beta gamma-subunit complex function in regulating effector activity. Furthermore, data for some G proteins suggest that they function as activated heterotrimers rather than as dissociated subunits.

PMID:
9113413
DOI:
10.1016/s0898-6568(96)00133-7
[Indexed for MEDLINE]

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