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Eur Cytokine Netw. 1997 Mar;8(1):83-90.

Growth hormone release of interleukin-1 alpha, interferon-gamma and interleukin-4 from murine splenocytes stimulated with staphylococcal protein A, toxic shock syndrome toxin-1 and streptococcal lysin S.

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1
Dipartimento di Patologia, Facolta' di Veterinaria, Universita' degli Studi di Napoli, Federico II Italy.

Abstract

We investigated changes in the IL-1 alpha, IFN-gamma and IL-4 release from splenocytes in the presence of growth hormone (GH). Splenocytes were stimulated with Protein A (PA), Toxic Shock Syndrome Toxin-1 (TSST-1) and Streptolysin S (SLS). In the presence of GH, splenocytes stimulated with PA, induced a 40% and 50% drop in IL-1 alpha and IFN-gamma release respectively, compared to controls, while no changes were shown in IL-4 release. The release of IFN-gamma by TSST-1-stimulated splenocytes fell by 30%, while no changes were shown in IL-1 alpha and IL-4 release after GH. The release of IL-1 alpha by SLS-stimulated splenocytes increased by 50% in the presence of GH. No changes were shown in IFN-gamma and IL-4 release. The results are discussed in terms of the possibility of an expanding function for these endocrine peptides within the immune system.

PMID:
9110153
[Indexed for MEDLINE]
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