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Nature. 1997 Apr 17;386(6626):671-4.

Mechanisms of angiogenesis.

Author information

1
Max-Planck-Institute for Physiological and Clinical Research, W.G. Kerckhoff Institute, Bad Nauheim, Germany.

Abstract

After the developing embryo has formed a primary vascular plexus by a process termed vasculogenesis, further blood vessels are generated by both sprouting and non-sprouting angiogenesis, which are progressively pruned and remodelled into a functional adult circulatory system. Recent results, particularly from the study of mice lacking some of the signalling systems involved, have greatly improved our understanding of the molecular basis underlying these events, and may suggest new approaches for treating conditions such as cancer that depend on angiogenesis.

PMID:
9109485
DOI:
10.1038/386671a0
[Indexed for MEDLINE]

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