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Microb Drug Resist. 1997 Spring;3(1):1-10.

Molecular analysis of putative pneumococcal virulence proteins.

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Molecular Microbiology Unit, Women's and Children's Hospital, North Adelaide, S.A., Australia.


Although the polysaccharide capsule has been recognized as a sine qua non of virulence, recent attention has focused on the role of pneumococcal proteins in pathogenesis, particularly in view of their potential as vaccine antigens. The contribution of pneumolysin, two distinct neuraminidases, autolysin, hyaluronidase, and the 37 kDa pneumococcal surface adhesin A has been examined by specifically mutagenizing the respective genes in the pneumococcal chromosome and examining the impact on virulence in animal models. The vaccine potential of these proteins has also been assessed by immunization of mice with purified antigens, followed by challenge with virulent pneumococci.

[Indexed for MEDLINE]

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