Format

Send to

Choose Destination
Microb Drug Resist. 1997 Spring;3(1):1-10.

Molecular analysis of putative pneumococcal virulence proteins.

Author information

1
Molecular Microbiology Unit, Women's and Children's Hospital, North Adelaide, S.A., Australia.

Abstract

Although the polysaccharide capsule has been recognized as a sine qua non of virulence, recent attention has focused on the role of pneumococcal proteins in pathogenesis, particularly in view of their potential as vaccine antigens. The contribution of pneumolysin, two distinct neuraminidases, autolysin, hyaluronidase, and the 37 kDa pneumococcal surface adhesin A has been examined by specifically mutagenizing the respective genes in the pneumococcal chromosome and examining the impact on virulence in animal models. The vaccine potential of these proteins has also been assessed by immunization of mice with purified antigens, followed by challenge with virulent pneumococci.

PMID:
9109091
DOI:
10.1089/mdr.1997.3.1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center