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FEBS Lett. 1997 Apr 1;405(3):281-4.

Ubiquitination of Na,K-ATPase alpha1 and alpha2 subunits.

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1
Department of Cellular and Molecular Biology, Harvard University, Cambridge, MA 02138, USA.

Abstract

Na,K-ATPase, an essential transporter of mammalian cells, is an oligomeric transmembrane protein composed of two subunits, alpha and beta, of which there are several isoforms. In this study, we demonstrate that the alpha1 and alpha2 isoforms of the Na,K-ATPase alpha subunit are modified by the covalent attachment of ubiquitin polymers in COS-7 cells. We propose that polyubiquitination of the Na,K-ATPase alpha subunit may play a role in regulating its degradation.

PMID:
9108305
[Indexed for MEDLINE]
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