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Semin Immunol. 1997 Feb;9(1):69-76.

Portrait of an executioner: the molecular mechanism of FAS/APO-1-induced apoptosis.

Author information

1
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA.

Abstract

Fas/APO-1 is a member of the TNF receptor family and plays a dominant role in the immune system, down-regulating the immune response and contributing to T-cell-mediated cytotoxicity. Activation of Fas/APO-1 by either natural ligand or agonist antibody initiates apoptosis. Until recently, however, the mechanism by which Fas/APO-1 engages the cell death machinery has been an enigma. Here we describe a proposed molecular mechanism by which this cell surface death receptor signals the suicide response.

PMID:
9106309
DOI:
10.1006/smim.1996.0055
[Indexed for MEDLINE]

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