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Ann N Y Acad Sci. 1997 Mar 15;813:733-7.

Endotoxin shock-associated hypothermia. How and why does it occur?

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Department of Physiology, University of Kanazawa Medical School, Japan.


In sum, our results indicate that LPS shock-associated hypothermia involves the following major mechanisms: 1) a decrease in the threshold Tb for activation of cold thermogenesis; 2) the resultant widening of the interthreshold zone; and 3) cold-seeking behavior. We speculate that, in severe systemic inflammation, this hypothermia constitutes an adaptive response.

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