Rising serum values of beta-subunit human chorionic gonadotrophin (hCG) in patients with progressive vulvar carcinomas

H W de Bruijn; K A ten Hoor; M Krans; A G van der Zee

doi:10.1038/bjc.1997.208

Rising serum values of beta-subunit human chorionic gonadotrophin (hCG) in patients with progressive vulvar carcinomas

Br J Cancer. 1997;75(8):1217-8. doi: 10.1038/bjc.1997.208.

Authors

H W de Bruijn¹, K A ten Hoor, M Krans, A G van der Zee

Affiliation

¹ Department of Obstetrics and Gynaecology, University Hospital Groningen, The Netherlands.

Abstract

Elevated serum levels of the beta-subunit of human chorionic gonadotrophin (hCG) were measured in 50% of patients with locoregional recurrences or progressive vulvar carcinoma (n = 14). At diagnosis of vulvar cancer, however, the incidence of elevated serum levels was low (5%) in 104 patients. The rising serum levels during progression of disease indicate that the synthesis of the beta-subunit hCG can be increased in vulvar carcinoma.

MeSH terms

Biomarkers, Tumor
Carcinoma, Squamous Cell / blood*
Carcinoma, Squamous Cell / physiopathology
Carcinoma, Squamous Cell / surgery
Chorionic Gonadotropin, beta Subunit, Human / blood*
Disease Progression
Female
Humans
Neoplasm Recurrence, Local
Neoplasm Staging
Vulvar Neoplasms / blood*
Vulvar Neoplasms / physiopathology
Vulvar Neoplasms / surgery

Substances

Biomarkers, Tumor
Chorionic Gonadotropin, beta Subunit, Human