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Curr Opin Immunol. 1997 Apr;9(2):183-8.

Advances in gene targeting methods.

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Institute for Genetics, Department for Immunology, Cologne, Germany.


Gene targeting in embryonic stem cells is commonly used for gene inactivation and the generation of mouse mutants. The combined use of methods for site-specific and homologous DNA recombination expands the potential of gene targeting in embryonic stem cells considerably and offers the opportunity of conditional gene targeting in mice.

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