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BMJ. 1997 Mar 29;314(7085):925-8.

Cohort study of association of risk of breast cancer with cyst type in women with gross cystic disease of the breast.

Author information

1
Unit of Clinical Epidemiology and Trials, National Institute for Cancer Research, Genova, Italy.

Abstract

OBJECTIVE:

To assess correlation between type of breast cyst and risk of breast cancer in women with gross cystic disease of the breast.

DESIGN:

Cohort study of women with breast cysts aspirated between 1983 and 1993 who were followed up until December 1994 for occurrence of breast cancer.

SETTING:

Major cancer prevention centre.

SUBJECTS:

802 women with aspirated breast cysts.

MAIN OUTCOME MEASURES:

Type of breast cyst based on cationic content of cyst fluid: type I (potassium:sodium ratio > 1.5), type II (potassium:sodium ratio < 1.5), or mixed (both types). Subsequent occurrence and type of breast cancer.

RESULTS:

After median follow up of six years (range 2-12 years) 15 cases of invasive breast cancer and two ductal carcinomas in situ were diagnosed in the cohort: 12 invasive cancers (and two carcinomas in situ) among the 417 women with type I cysts, two cancers among the 325 women with type II cysts, and one among the 60 women with mixed cysts. The incidence of breast cancer in women with type I cysts was significantly higher than that in women with type II cysts (relative risk 4.62 (95% confidence interval 1.26 to 29.7)). These results were confirmed after adjustment for several risk factors for breast cancer (relative risk 4.24 (1.12 to 27.5)).

CONCLUSIONS:

The increased risk of breast cancer of women with breast cysts seems to be concentrated among women with type I breast cysts.

PMID:
9099114
PMCID:
PMC2126378
DOI:
10.1136/bmj.314.7085.925
[Indexed for MEDLINE]
Free PMC Article

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