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Free Radic Biol Med. 1997;22(7):1259-69.

Age-associated alterations of the mitochondrial genome.

Author information

1
Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison 53706, USA.

Abstract

Age-associated alterations of the mitochondrial genome occur in several different species; however, their physiological relevance remains unclear. The age-associated changes of mitochondrial DNA (mtDNA) include nucleotide point mutations and modifications, as well as deletions. In this review, we summarize the current literature on age-associated mtDNA mutations and deletions and comment on their abundance. A clear need exists for a more thorough evaluation of the total damage to the mitochondrial genome that accumulates in aged tissues.

PMID:
9098100
DOI:
10.1016/s0891-5849(96)00546-1
[Indexed for MEDLINE]

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