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Cell. 1997 Apr 4;89(1):73-82.

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway.

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1
Department of Medicine, Oregon Health Sciences University L-474, Portland 97201, USA.

Abstract

Cyclic adenosine monophosphate (cAMP) has tissue-specific effects on growth, differentiation, and gene expression. We show here that cAMP can activate the transcription factor Elk-1 and induce neuronal differentiation of PC12 cells via its activation of the MAP kinase cascade. These cell type-specific actions of cAMP require the expression of the serine/threonine kinase B-Raf and activation of the small G protein Rap1. Rap1, activated by mutation or by the cAMP-dependent protein kinase PKA, is a selective activator of B-Raf and an inhibitor of Raf-1. Therefore, in B-Raf-expressing cells, the activation of Rap1 provides a mechanism for tissue-specific regulation of cell growth and differentiation via MAP kinase.

PMID:
9094716
[Indexed for MEDLINE]
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