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Curr Opin Struct Biol. 1997 Apr;7(2):266-72.

The ribosome at higher resolution--the donut takes shape.

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Wadsworth Center, New York State Department of Health, State University of New York at Albany, PO Box 509, Empire State Plaza, Albany, NY 12201-0509, USA.


Major new results in the 3D cryoimaging of ribosomes have advanced our understanding of ribosomal structure and function. For the first time, 3D difference maps have been used to image tRNA molecules in situ. With this new technology, the stage is set for detailed ligand-binding experiments that explore the binding states of elongation factors and tRNA, and that pinpoint locations of proteins and RNA on the surface of the ribosome.

[Indexed for MEDLINE]

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