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Curr Opin Struct Biol. 1997 Apr;7(2):279-84.

High resolution imaging of native biological sample surfaces using scanning probe microscopy.

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ME Müller Institute for Structural Biology, Biozentrum, Klingelbergstr 70, CH-4056, Basel, Switzerland.


The possibility of acquiring high resolution topographs using scanning probe microscopes under physiological conditions allows the observation of biomolecules at work. Progress has recently been made in imaging protein-DNA complexes, individual oligomers and protein arrays. Scanning probe microscopes are now tools that complement X-ray crystallography and electron microscopy.

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