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J Pediatr Gastroenterol Nutr. 1997 Jan;24(1):53-5.

Sensitivity and specificity of quantitative determination of pancreatic elastase 1 in feces of children.

Author information

1
Department of Pediatrics, University of Technology, Dresden, Germany.

Abstract

BACKGROUND:

The secretin-pancreozymin test has been accepted as the gold standard for testing exocrine pancreatic function. However, this test is invasive, time-consuming, and expensive. Therefore, in daily practice, more simple, indirect methods are proposed.

METHODS:

The fecal concentration of human pancreatic elastase (E1) has been assessed for diagnostic sensitivity and specificity. For sensitivity, fecal E1 determination in 23 healthy children were studied.

RESULTS:

Sensitivity to detect pancreatic insufficiency was 100% and specificity 96%.

CONCLUSIONS:

Fecal E1 concentration appears to be a more sensitive and specific test of pancreatic function than other tests.

[Indexed for MEDLINE]

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