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Fertil Steril. 1997 Apr;67(4):783-5.

Idiopathic hypogonadotropic hypogonadism in a male runner is reversed by clomiphene citrate.

Author information

1
University of New Mexico School of Medicine, Department of Medicine/Endocrinology-5ACC, Albuquerque 87131, USA.

Abstract

OBJECTIVE:

To assess the efficacy of estrogen antagonist therapy on the function of the hypothalamic-pituitary-testicular axis in a young male runner with significant morbidity attributable to idiopathic hypogonadotropic hypogonadism.

DESIGN:

An uncontrolled case study.

SETTING:

The outpatient endocrinology clinic of a university tertiary referral center.

PATIENT(S):

A 29-year-old male who has run 50 to 90 miles per week since 15 years of age and who presented with a pelvic stress fracture, markedly decreased bone mineral density, and symptomatic hypogonadotropic hypogonadism.

INTERVENTION(S):

Clomiphene citrate (CC) at doses up to 50 mg two times per day over a 5-month period.

MAIN OUTCOME MEASURE(S):

Serum concentrations of LH, FSH, and T before and after CC therapy, as well as clinical indicators of gonadal function.

RESULT(S):

Barely detectable levels of LH and FSH associated with hypogonadal levels of T were restored to the normal range with CC therapy. The patient experienced improved erectile function, increased testicular size and sexual hair growth, and an improved sense of well being.

CONCLUSION(S):

Exercise-induced hypogonadotropic hypogonadism exists as a clinical entity among male endurance athletes, and CC may provide a safe and effective treatment option for males with debilitating hypogonadism related to endurance exercise.

PMID:
9093212
[Indexed for MEDLINE]

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