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Fertil Steril. 1997 Apr;67(4):756-62.

The combination of testosterone undecanoate with tamoxifen citrate enhances the effects of each agent given independently on seminal parameters in men with idiopathic oligozoospermia.

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1
Endocrine Department, Elena Venizelou Hospital, Athens, Greece.

Abstract

OBJECTIVE:

To evaluate the effects of combined tamoxifen citrate and T undecanoate treatment on seminal parameters in men with idiopathic oligozoospermia.

DESIGN:

Prospective randomized clinical study.

SETTING:

A state hospital tertiary clinic.

PATIENT(S):

Eighty oligozoospermic men were included in the protocol.

INTERVENTION(S):

Patients were randomized to receive placebo, T undecanoate (40 mg three times per day), tamoxifen citrate (10 mg two times per day), or T undecanoate plus tamoxifen citrate.

RESULT(S):

Tamoxifen citrate plus T undecanoate treatment produced a satisfactory improvement of total sperm number, motility, and functional sperm fraction after 3 and 6 months. Comparisons with other active treatment groups showed significantly higher increment values for motility and functional fraction, whereas aniline, acrosine, and free L-carnitine also were markedly better in the combination treatment group.

CONCLUSION(S):

These results indicate that the combination of tamoxifen citrate with T undecanoate not only improves significantly important seminal parameters but also compares favorably with the single treatments used. Therefore, this combination deserves a place as a first line of treatment in idiopathic oligozoospermia.

PMID:
9093207
[Indexed for MEDLINE]
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