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Science. 1997 Apr 11;276(5310):266-9.

Trafficking of matrix collagens through bone-resorbing osteoclasts.

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  • 1Bone and Mineral Centre, Department of Medicine, University College London Medical School, University College London, London WIN 8AA, UK.


An intracellular pathway for proteins liberated from mineralized matrix during resorption was identified in osteoclasts. Analysis by confocal microscopy of sites of active bone resorption showed that released matrix proteins, including degraded type I collagen, were endocytosed along the ruffled border within the resorption compartment and transcytosed through the osteoclast to the basolateral membrane. Intracellular trafficking of degraded collagen, as typified by the resorbing osteoclast, may provide the cell with a regulatory mechanism for the control of tissue degradation.

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