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Gastroenterol Clin Biol. 1997;21(1):7-11.

[Effect of low-dose polyethylene glycol 4000 on fecal consistency and dilution water in healthy subjects].

[Article in French]

Author information

1
Hôpital Saint-Lazare, Paris.

Abstract

OBJECTIVES:

The aim of the study was to assess in normal subjects the changes in stool consistency and dilution water during the ingestion of small doses of polyethylene glycol (PEG) 5.9 g/d. Dilution water is the water located outside solid structures (bacteria and food residue).

METHODS:

Each stool passed by 16 non-constipated male volunteers was collected during 3 weeks. PEG was ingested from days 1 to 7, and stools collected during the ingestion of PEG were compared with those collected at least 24 h after the last fecal excretion of PEG (control fecal data). Consistency, fresh and dry weight, dilution water, nitrogen, electrolytes and PEG were quantified in each stool.

RESULTS:

Stools were softer during the ingestion of PEG (P < 0.01) and dilution water increased significantly (49.4 +/- 1.7 vs 37.6 +/- 2.6 mL/100 g feces, mean +/- SD, P < 0.02). PEG induced variable effects among individuals according to the consistency and dilution water measured during the control period.

CONCLUSION:

Low doses of PEG (5.9 g/d) soften stools particularly when feces are harder. This effect is due to changes in dilution water (water outside fecal solid structures).

PMID:
9091392
[Indexed for MEDLINE]
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