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Fertil Steril. 1997 Mar;67(3):553-8.

Reduction of adhesion formation with hyaluronic acid after peritoneal surgery in rabbits.

Author information

1
Livingston Reproductive Biology Laboratory, University of Southern California School of Medicine, Los Angeles 90033, USA.

Abstract

OBJECTIVE:

To examine the effect of hyaluronic acid, a high-molecular-weight glucosaminoglycan found in the extracellular matrix, on the formation of adhesions, a major source of postoperative complications.

DESIGN:

The ability of hyaluronic acid to reduce adhesion formation was evaluated using a standardized rabbit model. The material was administered i.p. at the end of surgery.

SETTING:

University laboratory.

ANIMAL(S):

New Zealand White female rabbits.

INTERVENTION(S):

Intraperitoneal administration of various formulations of hyaluronic acid at the end of surgery.

MAIN OUTCOME MEASURE(S):

One week after surgery, a second laparotomy was performed and the extent of adhesion formation was determined.

RESULT(S):

Five separate molecular weight ranges of hyaluronic acid representing eight viscosities between 1,000 and 12,000 centipoise (CPS) were shown to reduce adhesion formation in this model. All volumes, 1 to 30 mL, of hyaluronic acid tested reduced adhesion formation. In addition, the low-viscosity, low-molecular-weight hyaluronic acid significantly reduced adhesion formation when added to the trauma site or when injected at a site remote from the trauma area.

CONCLUSION(S):

This study showed that hyaluronic acid administered at the end of surgery reduced adhesion formation.

PMID:
9091346
[Indexed for MEDLINE]

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