The Arabidopsis NIM1 protein shows homology to the mammalian transcription factor inhibitor I kappa B

Plant Cell. 1997 Mar;9(3):425-39. doi: 10.1105/tpc.9.3.425.

Abstract

The NIM1 (for noninducible immunity) gene product is involved in the signal transduction cascade leading to both systemic acquired resistance (SAR) and gene-for-gene disease resistance in Arabidopsis. We have isolated and characterized five new alleles of nim1 that show a range of phenotypes from weakly impaired in chemically induced pathogenesis-related protein-1 gene expression and fungal resistance to very strongly blocked. We have isolated the NIM1 gene by using a map-based cloning procedure. Interestingly, the NIM1 protein shows sequence homology to the mammalian signal transduction factor I kappa B subclass alpha. NF-kappa B/I kappa B signaling pathways are implicated in disease resistance responses in a range of organisms from Drosophila to mammals, suggesting that the SAR signaling pathway in plants is representative of an ancient and ubiquitous defense mechanism in higher organisms.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Arabidopsis / genetics
  • Arabidopsis / physiology*
  • Arabidopsis Proteins*
  • Base Sequence
  • DNA Transposable Elements
  • DNA-Binding Proteins / chemistry*
  • I-kappa B Proteins
  • Immunity, Innate
  • Mammals
  • Mice
  • Molecular Sequence Data
  • Mutation*
  • NF-KappaB Inhibitor alpha
  • Plant Diseases / microbiology
  • Plant Proteins / biosynthesis
  • Plant Proteins / chemistry
  • Plant Proteins / genetics*
  • Point Mutation
  • Proto-Oncogene Proteins / chemistry*
  • Rats
  • Restriction Mapping
  • Sequence Deletion
  • Sequence Homology, Amino Acid
  • Swine

Substances

  • Arabidopsis Proteins
  • DNA Transposable Elements
  • DNA-Binding Proteins
  • I-kappa B Proteins
  • NPR1 protein, Arabidopsis
  • Nfkbia protein, mouse
  • Nfkbia protein, rat
  • Plant Proteins
  • Proto-Oncogene Proteins
  • NF-KappaB Inhibitor alpha

Associated data

  • GENBANK/U87794