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J Nat Prod. 1997 Mar;60(3):309-11.

Rigidone, a sesquiterpene o-quinone from the gorgonian Pseudopterogorgia rigida.

Author information

1
Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, Research and Development, King of Prussia, Pennsylvania 19406-0939, USA. Alan_J_Freyer@sbphrd.com

Abstract

As part of a search for novel biologically active compounds in the Macrophage Scavenger Receptor (MSR) assay, the EtOAc extract of a gorgonian coral, Pseudopterogorgia rigida, was shown to be active. Bioassay-guided fractionation of the extract yielded curcuphenol, curcuhydroquinone, curcuquinone, and a novel o-quinone, rigidone (1). The structure and stereochemistry of 1 was determined by interpretation of spectral data and chemical transformation.

PMID:
9090873
DOI:
10.1021/np960653m
[Indexed for MEDLINE]
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