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JAMA. 1997 Apr 9;277(14):1156-8.

Measles reimmunization in children seronegative after initial immunization.

Author information

1
Mayo Vaccine Research Group, Mayo Clinic and Foundation, Rochester, Minn 55905, USA.

Abstract

OBJECTIVE:

To evaluate the success of measles reimmunization in children without measles antibody after the initial dose of measles vaccine.

DESIGN AND SETTING:

A prospective clinical trial in Olmsted County, Minnesota, and Northern Newfoundland and Labrador in Canada.

SUBJECTS:

A total of 130 healthy white, Innu, and Inuit schoolchildren. All subjects had received the post-1980 Moraten measles vaccine 4 to 11 years earlier.

METHODS:

Children previously identified as measles antibody seronegative or equivocal after 1 dose of measles vaccine were entered into the trial and reimmunized. Measles antibody was measured a minimum of 6 weeks later using a whole-virus IgG measles-specific enzyme-linked immunoassay (EIA).

RESULTS:

Of the 130 children reimmunized, 106 (81.5%) became measles antibody seropositive, but 24 children (18.5%) remained seronegative. Younger age at initial immunization (<13 months vs > or = 13 months) was significantly associated with lack of seropositive antibody levels following reimmunization (odds ratio, 3.9; 95% confidence interval, 1.5-9.7). In addition, antibody levels after reimmunization were significantly reduced with increasing time since initial immunization (P=.001).

CONCLUSIONS:

After 2 doses of measles vaccine, 98.2% of all subjects in this study were seropositive for measles antibody, despite the fact that almost 20% of children did not have measurable antibodies 4 to 11 years following a first dose. These findings suggest that the current public health policy recommending a 2-dose measles immunization strategy, with the second dose given at school entry, will provide high levels of immunity in the community.

PMID:
9087472
[Indexed for MEDLINE]

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