p53 and tumour viruses: catching the guardian off-guard

J C Neil; E R Cameron; E W Baxter

doi:10.1016/S0966-842X(96)10083-4

p53 and tumour viruses: catching the guardian off-guard

Trends Microbiol. 1997 Mar;5(3):115-20. doi: 10.1016/S0966-842X(96)10083-4.

Authors

J C Neil¹, E R Cameron, E W Baxter

Affiliation

¹ Dept of Veterinary Pathology, University of Glasgow, Bearsden, UK. j.c.neil@vet.gla.ac.uk

PMID: 9080610
DOI: 10.1016/S0966-842X(96)10083-4

Abstract

Oncogenic viruses have evolved direct and indirect mechanisms to overcome the tumour suppressor p53. Fortunately, tumour development is limited by the narrow cell tropisms of the viruses concerned and the host immune response. However, such viruses are helping to elucidate the p53 response pathway and may play a future role as novel cancer therapeutic agents.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Neoplasms / genetics
Neoplasms / virology
Oncogenic Viruses / immunology
Oncogenic Viruses / physiology*
Tumor Suppressor Protein p53 / genetics
Tumor Suppressor Protein p53 / metabolism
Tumor Suppressor Protein p53 / physiology*

Substances

Tumor Suppressor Protein p53